Publications from 2004-present

For a recent overview of all my publications, you also can go directly to PubMed by clicking here!

    2011
  • van Mens SP, Meijvis SC, Endeman H, van Velzen-Blad H, Biesma DH, Grutters JC, Vlaminckx BJ, Rijkers GT.
    Longitudinal Analysis of Pneumococcal Antibodies during Community-acquired Pneumonia Reveals a Much Higher Involvement of Streptococcus pneumoniae than Estimated by Conventional Methods Alone. Clin Vaccine Immunol. 2011 Mar 2. [Epub ahead of print] PMID: 21367978 [PubMed - as supplied by publisher]

  • Meerveld-Eggink A, de Weerdt O, van der Velden AM, Los M, van der Velden AW, Stouthard JM, Nijziel MR, Westerman M, Beeker A, van Beek R, Rimmelzwaan GF, Rijkers GT, Biesma DH.
    Response to influenza virus vaccination during chemotherapy in patients with breast cancer. Ann Oncol. 2011 Feb 8. [Epub ahead of print] PMID: 21303799 [PubMed - as supplied by publisher]

  • Meijvis SC, Grutters JC, Thijsen SF, Rijkers GT, Biesma DH, Endeman H.
    Therapy in pneumonia: What is beyond antibiotics? Neth J Med. 2011 Jan;69(1):21-6. PMID: 21325697 [PubMed - in process] Free Article


    • 2010
  • Meerveld-Eggink A, de Weerdt O, de Voer RM, Berbers GA, van Velzen-Blad H, Vlaminckx BJ, Biesma DH, Rijkers GT.
    Impaired antibody response to conjugated meningococcal serogroup C vaccine in asplenic patients. Eur J Clin Microbiol Infect Dis. 2010 Dec 24. [Epub ahead of print] PMID: 21184126 [PubMed - as supplied by publisher]

  • Wiertz K, De Visser L, Rijkers G, De Groot-Mijnes J, Los L, Rothova A.
    Intraocular and serum levels of vascular endothelial growth factor in acute retinal necrosis and ocular toxoplasmosis. Retina. 2010 Nov-Dec;30(10):1734-8. PMID: 20706172 [PubMed - indexed for MEDLINE]

  • Meerveld-Eggink A, de Weerdt O, van Velzen-Blad H, Biesma DH, Rijkers GT.
    Response to conjugate pneumococcal and Haemophilus influenzae type b vaccines in asplenic patients. Vaccine. 2010 Nov 26. [Epub ahead of print] PMID: 21115060 [PubMed - as supplied by publisher]

  • Safari D, Dekker HA, Rijkers G, Snippe H.
    Codelivery of adjuvants at the primary immunization site is essential for evoking a robust immune response to neoglycoconjugates. Vaccine. 2010 Nov 24. [Epub ahead of print] PMID: 21111776 [PubMed - as supplied by publisher]

  • Rijkers GT, van Mens SP, van Velzen-Blad H.
    What do the next 100 years hold for pneumococcal vaccination? Expert Rev Vaccines. 2010 Nov;9(11):1241-4. No abstract available. PMID: 21087102 [PubMed - in process]

  • Endeman H, Meijvis SC, Rijkers GT, van Velzen-Blad H, van Moorsel CH, Grutters JC, Biesma DH.
    Systemic cytokine response in patients with community-acquired pneumonia. Eur Respir J. 2010 Sep 30. [Epub ahead of print]PMID: 20884746 [PubMed - as supplied by publisher]

  • van de Kant KD, Klaassen EM, Jöbsis Q, Koers K, Rijkers GT, van der Grinten CP, van Schayck OC, Passos VL, Dompeling E.
    Wheezing in preschool children is associated with increased levels of cytokines/chemokines in exhaled breath condensate. Allergy Clin Immunol. 2010 Sep;126(3):669-71. No abstract available. PMID: 20816200 [PubMed - indexed for MEDLINE]

  • Veltkamp M, Van Moorsel CH, Rijkers GT, Ruven HJ, Van Den Bosch JM, Grutters JC.
    Toll-like receptor (TLR)-9 genetics and function in sarcoidosis. Clin Exp Immunol. 2010 Oct;162(1):68-74. doi: 10.1111/j.1365-2249.2010.04205.x. Epub 2010 Aug 19.PMID: 20659127 [PubMed - indexed for MEDLINE]

  • Kastelijn EA, Rijkers GT, Van Moorsel CH, Zanen P, Kwakkel-van Erp JM, Van De Graaf EA, Van Kessel DA, Grutters JC, Van Den Bosch JM.
    Systemic and exhaled cytokine and chemokine profiles are associated with the development of bronchiolitis obliterans syndrome. J Heart Lung Transplant. 2010 Sep;29(9):997-1008. Epub 2010 Jun 8.PMID: 20627628 [PubMed - in process]

  • Kastelijn EA, van Moorsel CH, Rijkers GT, Ruven HJ, Karthaus V, Kwakkel-van Erp JM, van de Graaf EA, Zanen P, van Kessel DA, Grutters JC, van den Bosch JM.
    Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation. J Heart Lung Transplant. 2010 Jun;29(6):665-71. Epub 2010 Mar 15.PMID: 20227302 [PubMed - indexed for MEDLINE]

  • Robroeks CM, Rijkers GT, Jöbsis Q, Hendriks HJ, Damoiseaux JG, Zimmermann LJ, van Schayck OP, Dompeling E.
    Increased cytokines, chemokines and soluble adhesion molecules in exhaled breath condensate of asthmatic children. Clin Exp Allergy. 2010 Jan;40(1):77-84. PMID: 20205697 [PubMed - indexed for MEDLINE]

  • Rijkers GT, Bengmark S, Enck P, Haller D, Herz U, Kalliomaki M, Kudo S, Lenoir-Wijnkoop I, Mercenier A, Myllyluoma E, Rabot S, Rafter J, Szajewska H, Watzl B, Wells J, Wolvers D, Antoine JM.
    Guidance for substantiating the evidence for beneficial effects of probiotics: current status and recommendations for future research. J Nutr. 2010 Mar;140(3):671S-6S. Epub 2010 Feb 3.PMID: 20130080 [PubMed - indexed for MEDLINE]

  • Kalliomäki M, Antoine JM, Herz U, Rijkers GT, Wells JM, Mercenier A.
    Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of allergic diseases by probiotics. J Nutr. 2010 Mar;140(3):713S-21S. Epub 2010 Feb 3.PMID: 20130079 [PubMed - indexed for MEDLINE]

  • Haller D, Antoine JM, Bengmark S, Enck P, Rijkers GT, Lenoir-Wijnkoop I.
    Guidance for substantiating the evidence for beneficial effects of probiotics: probiotics in chronic inflammatory bowel disease and the functional disorder irritable bowel syndrome. J Nutr. 2010 Mar;140(3):690S-7S. Epub 2010 Jan 27. Review. Erratum in: J Nutr. 2010 Jun;140(6):1189. PMID: 20107148 [PubMed - indexed for MEDLINE]

  • Rabot S, Rafter J, Rijkers GT, Watzl B, Antoine JM.
    Guidance for substantiating the evidence for beneficial effects of probiotics: impact of probiotics on digestive system metabolism. J Nutr. 2010 Mar;140(3):677S-89S. Epub 2010 Jan 27.PMID: 20107147 [PubMed - indexed for MEDLINE]

  • Wolvers D, Antoine JM, Myllyluoma E, Schrezenmeir J, Szajewska H, Rijkers GT.
    Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of infections by probiotics. J Nutr. 2010 Mar;140(3):698S-712S. Epub 2010 Jan 27. Review.PMID: 20107143 [PubMed - indexed for MEDLINE]

  • Pot GK, Geelen A, Majsak-Newman G, Harvey LJ, Nagengast FM, Witteman BJ, van de Meeberg PC, Hart AR, Schaafsma G, Lund EK, Rijkers GT, Kampman E.
    Increased consumption of fatty and lean fish reduces serum C-reactive protein concentrations but not inflammation markers in feces and in colonic biopsies. J Nutr. 2010 Feb;140(2):371-6. Epub 2009 Dec 23.PMID: 20032491 [PubMed - indexed for MEDLINE]

  • de Roock S, van Elk M, van Dijk ME, Timmerman HM, Rijkers GT, Prakken BJ, Hoekstra MO, de Kleer IM.
    Lactic acid bacteria differ in their ability to induce functional regulatory T cells in humans. Clin Exp Allergy. 2010 Jan;40(1):103-10. Epub 2009 Oct 7.PMID: 19817754 [PubMed - indexed for MEDLINE]


    • 2009
  • Meerveld-Eggink A, van der Velden AM, Ossenkoppele GJ, van de Loosdrecht AA, Biesma DH, Rijkers GT.
    Antibody response to polysaccharide conjugate vaccines after nonmyeloablative allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2009 Dec;15(12):1523-30. Epub 2009 Sep 25.PMID: 19896075 [PubMed - indexed for MEDLINE]

  • de Voer RM, van der Klis FR, Engels CW, Schepp RM, van de Kassteele J, Sanders EA, Rijkers GT, Berbers GA.
    Kinetics of antibody responses after primary immunization with meningococcal serogroup C conjugate vaccine or secondary immunization with either conjugate or polysaccharide vaccine in adults. Vaccine. 2009 Nov 23;27(50):6974-82. Epub 2009 Oct 1.PMID: 19800445 [PubMed - indexed for MEDLINE]

  • de Jager W, Bourcier K, Rijkers GT, Prakken BJ, Seyfert-Margolis V.
    Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays. BMC Immunol. 2009 Sep 28. 10:52.PMID: 19785746 [PubMed - indexed for MEDLINE]

  • de Voer RM, van der Klis FR, Niers LE, Rijkers GT, Berbers GA.
    Absence of Neisseria meningitidis Serogroup C-Specific Antibodies during the first year of life in the Netherlands: An Age-Group at Risk? Clin Vaccine Immunol. 2009 Aug 19. [Epub ahead of print] PMID: 19692627 [PubMed - as supplied by publisher]

  • Pot GK, Brouwer IA, Enneman A, Rijkers GT, Kampman E, Geelen A.
    No effect of fish oil supplementation on serum inflammatory markers and their interrelationships: a randomized controlled trial in healthy, middle-aged individuals. Eur J Clin Nutr. 2009 Jul 22. [Epub ahead of print] PMID: 19623203 [PubMed - as supplied by publisher]

  • Spanjaard L, Rijkers GT.
    Haemophilus influenzae serotype b vaccine failure: what is the significance of antibody levels? Clin Infect Dis. 2009 Aug 1;49(3):381-2. No abstract available. PMID: 19580417 [PubMed - indexed for MEDLINE]

  • Rosias PP, Robroeks CM, van de Kant KD, Rijkers GT, Zimmermann LJ, van Schayck CP, Heynens JW, Jöbsis Q, Dompeling E.
    Feasibility of a new method to collect exhaled breath condensate in pre-school children. Pediatr Allergy Immunol. 2009 Jun 26. [Epub ahead of print] PMID: 19563465 [PubMed - as supplied by publisher]

  • Endeman H, Cornips MC, Grutters JC, van den Bosch JM, Ruven HJ, van Velzen-Blad H, Rijkers GT, Biesma DH.
    The Fcgamma receptor IIA-R/R131 genotype is associated with severe sepsis in community-acquired pneumonia. Clin Vaccine Immunol. 2009 Jul;16(7):1087-90. Epub 2009 Jun 3. PMID: 19494086 [PubMed - indexed for MEDLINE]

  • Niers L, Martín R, Rijkers G, Sengers F, Timmerman H, van Uden N, Smidt H, Kimpen J, Hoekstra M.
    The effects of selected probiotic strains on the development of eczema (the PandA study). Allergy. 2009 Sep;64(9):1349-58. Epub 2009 Apr 9. PMID: 19392993 [PubMed - in process]

  • Smit LA, Heederik D, Doekes G, Krop EJ, Rijkers GT, Wouters IM.
    Ex vivo cytokine release reflects sensitivity to occupational endotoxin exposure. Eur Respir J. 2009 Apr 8. [Epub ahead of print] PMID: 19357150 [PubMed - as supplied by publisher]

  • Vlieger AM, Robroch A, van Buuren S, Kiers J, Rijkers G, Benninga MA, te Biesebeke R.
    Tolerance and safety of Lactobacillus paracasei ssp. paracasei in combination with Bifidobacterium animalis ssp. lactis in a prebiotic-containing infant formula: a randomised controlled trial. Br J Nutr. 2009 Sep;102(6):869-75. Epub 2009 Mar 31. PMID: 19331702 [PubMed - in process]

  • Lutgendorff F, Nijmeijer RM, Sandström PA, Trulsson LM, Magnusson KE, Timmerman HM, van Minnen LP, Rijkers GT, Gooszen HG, Akkermans LM, Söderholm JD.
    Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis. PLoS One. 2009;4(2):e4512. Epub 2009 Feb 18. PMID: 19223985 [PubMed - indexed for MEDLINE]

  • Rychter JW, van Minnen LP, Verheem A, Timmerman HM, Rijkers GT, Schipper ME, Gooszen HG, Akkermans LM, Kroese AB.
    Pretreatment but not treatment with probiotics abolishes mouse intestinal barrier dysfunction in acute pancreatitis. Surgery. 2009 Feb; 145(2):157-67. PMID: 19167970 [PubMed - in process]

  • Herpers BL, Yzerman EP, de Jong BA, Bruin JP, Lettinga KD, Kuipers S, Den Boer JW, van Hannen EJ, Rijkers GT, van Velzen-Blad H, de Jongh BM.
    Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-sufficient genotypes in an outbreak of Legionella pneumophila pneumonia. Hum Immunol. 2009 Feb;70(2):125-9.Epub 2008 Dec 13. PMID: 19073229 [PubMed - indexed for MEDLINE]

  • Herpers BL, de Jong BA, Dekker B, Aerts PC, van Dijk H, Rijkers GT, van Velzen-Blad H.
    Hemolytic assay for the measurement of functional human mannose-binding lectin: A modification to avoid interference from classical pathway activation. J Immunol Methods. 2009 Jan 23.[Epub ahead of print] PMID: 19171151 [PubMed - as supplied by publisher]

  • de Jager W, Prakken B, Rijkers GT.
    Cytokine multiplex immunoassay: methodology and (clinical) applications. Methods Mol Biol. 2009; 514:119-33. PMID: 19048217 [PubMed - in process]


    • 2008

  • Meerveld-Eggink A, de Weerdt O, Rijkers GT, van Velzen-Blad H, Biesma DH.
    Vaccination coverage and awareness of infectious risks in patients with an absent or dysfunctional spleen in the Netherlands. Vaccine. 2008 Dec 9; 26(52):6975-9. Epub 2008 Oct 9. PMID: 18848594 [PubMed - in process]

  • Herpers BL, Yzerman EP, Jong BA, Bruin JP, Lettinga KD, Kuipers S, Boer JW, Hannen EJ, Rijkers GT, van Velzen-Blad H, Jongh BM.
    Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-sufficient genotypes in an outbreak of Legionella pneumophila pneumonia. Hum Immunol. 2008 Dec 13.. [Epub ahead of print] PMID: 19073229 [PubMed - as supplied by publisher]

  • Sijssens KM, Rijkers GT, Rothova A, Stilma JS, de Boer JH.
    Distinct cytokine patterns in the aqueous humor of children, adolescents and adults with uveitis. Ocul Immunol Inflamm. 2008 Sep-Oct; 16(5):211-6. PMID: 19065415 [PubMed - in process]

  • Lutgendorff F, Trulsson LM, van Minnen LP, Rijkers GT, Timmerman HM, Franzén LE, Gooszen HG, Akkermans LM, Söderholm JD, Sandström PA.
    Probiotics enhance pancreatic glutathione biosynthesis and reduce oxidative stress in experimental acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G1111-21. Epub 2008 Oct 2. PMID: 18832452 [PubMed - indexed for MEDLINE]

  • Robroeks CM, van de Kant KD, van Vliet D, Kester AD, Hendriks HJ, Damoiseaux JG, Wodzig WK, Rijkers GT, Dompeling E, Jöbsis Q.
    Comparison of the anti-inflammatory effects of extra-fine hydrofluoroalkane-beclomethasone vs fluticasone dry powder inhaler on exhaled inflammatory markers in childhood asthma. Ann Allergy Asthma Immunol. 2008 Jun; 100(6):601-7. PMID: 18592826 [PubMed - indexed for MEDLINE]

  • de Voer RM, van der Klis FR, Engels CW, Rijkers GT, Sanders EA, Berbers GA.
    Development of a fluorescent-bead-based multiplex immunoassay to determine immunoglobulin G subclass responses to Neisseria meningitidis serogroup A and C polysaccharides. Clin Vaccine Immunol. 2008 Aug; 15(8):1188-93. Epub 2008 Jun 11. PMID: 18550729 [PubMed - indexed for MEDLINE]

  • Gelinck LB, van der Bijl AE, Visser LG, Huizinga TW, van Hogezand RA, Rijkers GT, Kroon FP.
    CD14 genetics in sarcoidosis patients; who's in control? Vaccine. 2008 Jun 25; 26(27-28):3528-33. Epub 2008 May 2. PMID: 18502006 [PubMed - indexed for MEDLINE]

  • Dentener MA, Creutzberg EC, Pennings HJ, Rijkers GT, Mercken E, Wouters EF.
    Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: a pilot study. Respiration. 2008; 76(3):275-82. Epub 2008 Feb 15. PMID: 18277064 [PubMed - indexed for MEDLINE]

  • Kuijk LM, Mandey SH, Schellens I, Waterham HR, Rijkers GT, Coffer PJ, Frenkel J.
    Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1. Mol Immunol. 2008 Jan 31; [Epub ahead of print] PMID: 18242710 [PubMed - as supplied by publisher]

  • Rosias PP, Robroeks CM, Kester A, den Hartog GJ, Wodzig WK, Rijkers GT, Zimmermann LJ, van Schayck CP, Jöbsis Q, Dompeling E.
    Biomarker reproducibility in exhaled breath condensate collected with different condensers. Eur Respir J. 2008 Jan 9; [Epub ahead of print] PMID: 18184682 [PubMed - as supplied by publisher]


    • 2007

  • van der Velden AM, Claessen AM, van Velzen-Blad H, de Groot MR, Kramer MH, Biesma DH, Rijkers GT.
    Vaccination responses and lymphocyte subsets after autologous stem cell transplantation. Vaccine. 2007 Oct 25; [Epub ahead of print] PMID: 17996989 [PubMed - as supplied by publisher]

  • Steenhuis TJ, van Aalderen WM, Bloksma N, Nijkamp FP, van der Laag J, van Loveren H, Rijkers GT, Kuis W, Hoekstra MO.
    Bacille-Calmette-Guerin vaccination and the development of allergic disease in children: a randomized, prospective, single-blind study. Clin Exp Allergy. 2007 Oct 23; [Epub ahead of print] PMID: 17956585 [PubMed - as supplied by publisher]

  • Smit LA, Bongers SI, Ruven HJ, Rijkers GT, Wouters IM, Heederik D, Omland O, Sigsgaard T.
    Atopy and new-onset asthma in young Danish farmers and CD14, TLR2, and TLR4 genetic polymorphisms: a nested case-control study. Clin Exp Allergy. 2007 Sep 17; [Epub ahead of print]

  • Niers L, Stasse-Wolthuis M, Rombouts FM, Rijkers GT.
    Nutritional support for the infant's immune system. Nutr Rev. 2007 Aug;65(8 Pt 1):347-60.

  • Krediet TG, Wiertsema SP, Vossers MJ, Hoeks SB, Fleer A, Ruven HJ, Rijkers GT.
    Toll-like Receptor 2 Polymorphism Is Associated With Preterm Birth. Pediatr Res. 2007 Jul 24;Publish Ahead of Print [Epub ahead of print]

  • Sijssens KM, Rijkers GT, Rothova A, Stilma JS, Schellekens PA, de Boer JH.
    Cytokines, chemokines and soluble adhesion molecules in aqueous humor of children with uveitis. Exp Eye Res. 2007 Jun 22; [Epub ahead of print]

  • Veltkamp M, Wijnen PA, van Moorsel CH, Rijkers GT, Ruven HJ, Heron M, Bekers O, Claessen AM, Drent M, van den Bosch JM, Grutters JC.
    Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis. Clin Exp Immunol. 2007 Sep;149(3):453-62. Epub 2007 Jun 12.

  • van der Velden AM, Claessen AM, van Velzen-Blad H, Biesma DH, Rijkers GT.
    Development of T cell-mediated immunity after autologous stem cell transplantation: prolonged impairment of antigen-stimulated production of gamma-interferon. Bone Marrow Transplant. 2007 Aug;40(3):261-6. Epub 2007 Jun 11.

  • Timmerman HM, Niers LE, Ridwan BU, Koning CJ, Mulder L, Akkermans LM, Rombouts FM, Rijkers GT.
    Design of a multispecies probiotic mixture to prevent infectious complications in critically ill patients. Clin Nutr. 2007 Aug;26(4):450-9. Epub 2007 Jun 4.

  • Van der Velden AM, Van Velzen-Blad H, Claessen AM, Van der Griend R, Oltmans R, Rijkers GT, Biesma DH.
    The effect of ranitidine on antibody responses to polysaccharide vaccines in patients with B-cell chronic lymphocytic leukaemia. Eur J Haematol. 2007 Jul;79(1):47-52. Epub 2007 May 28.

  • Niers LE, Hoekstra MO, Timmerman HM, van Uden NO, de Graaf PM, Smits HH, Kimpen JL, Rijkers GT.
    Selection of probiotic bacteria for prevention of allergic diseases: immunomodulation of neonatal dendritic cells. Clin Exp Immunol. 2007 Aug;149(2):344-52. Epub 2007 May 22.

  • van Minnen LP, Timmerman HM, Lutgendorff F, Verheem A, Harmsen W, Konstantinov SR, Smidt H, Visser MR, Rijkers GT, Gooszen HG, Akkermans LM.
    Modification of intestinal flora with multispecies probiotics reduces bacterial translocation and improves clinical course in a rat model of acute pancreatitis. Surgery. 2007 Apr;141(4):470-80.

  • van der Ent CK, Hoekstra H, Rijkers GT.
    Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody. Thorax. 2007 Mar;62(3):276-7. PMID: 17329558 [PubMed - indexed for MEDLINE]

  • Visser N, van Rijn BB, Rijkers GT, Franx A, Bruinse HW. Inflammatory
    Inflammatory changes in preeclampsia: current understanding of the maternal innate and adaptive immune response. Obstet Gynecol Surv. 2007 Mar;62(3):191-201. Review. PMID: 17306041 [PubMed - indexed for MEDLINE]

  • Zonneveld-Huijssoon E, Ronaghy A, Van Rossum MA, Rijkers GT, van der Klis FR, Sanders EA, Vermeer-De Bondt PE, Hoes AW, van der Net JJ, Engels C, Kuis W, Prakken BJ, Van Tol MJ, Wulffraat NM.
    Safety and efficacy of meningococcal c vaccination in juvenile idiopathic arthritis. Arthritis Rheum. 2007 Feb;56(2):639-46. PMID: 17265499 [PubMed - indexed for MEDLINE]

  • Hettinga YM, Verdonck LF, Fijnheer R, Rijkers GT, Rothova A.
    Anterior uveitis: a manifestation of graft-versus-host disease. Ophthalmology. 2007 Apr;114(4):794-7. Epub 2006 Dec 20. PMID: 17187864 [PubMed - indexed for MEDLINE]

  • Wiertsema SP, Baynam G, Khoo SK, Veenhoven RH, van Heerbeek N, Zhang G, Laing IA, Rijkers GT, Goldblatt J, Sanders EA, Le Souef PN.
    Impact of genetic variants in IL-4, IL-4 RA and IL-13 on the anti-pneumococcal antibody response. Vaccine. 2007 Jan 4;25(2):306-13. Epub 2006 Aug 2. PMID: 16914241 [PubMed - indexed for MEDLINE]

  • Wiertsema SP, Khoo SK, Baynam G, Veenhoven RH, Laing IA, Zielhuis GA, Rijkers GT, Goldblatt J, Lesouef PN, Sanders EA.
    Association of CD14 promoter polymorphism with otitis media and pneumococcal vaccine responses. Clin Vaccine Immunol. 2006 Aug;13(8):892-7. Erratum in: Clin Vaccine Immunol. 2006 Dec;13(12):1375. PMID: 16893989 [PubMed - indexed for MEDLINE]

  • Damoiseaux J, Rijkers G, Tervaert JW.
    Pneumococcal vaccination does not increase circulating levels of IgM antibodies to oxidized LDL in humans and therefore precludes an anti-atherogenic effect. Atherosclerosis. 2007 Jan;190(1):10-1. Epub 2006 Jun 13. No abstract available. PMID: 16774756 [PubMed - indexed for MEDLINE]

    • 2006

  • Brandsma D, Voest EE, de Jager W, Bonfrer H, Algra A, Boogerd W, Korse T, Reijneveld JC, Verbeek MM, Rijkers G, Taphoorn MJ.
    CSF protein profiling using Multiplex Immuno-assay : A potential new diagnostic tool for leptomeningeal metastases. J Neurol. 2006 Sep; 253(9):1177-84. Epub 2006 Sep 22. PMID: 16998648 [PubMed - in process]

  • van den Akker EH, Sanders EA, van Staaij BK, Rijkers GT, Rovers MM, Hoes AW, Schilder AG.
    Long-term effects of pediatric adenotonsillectomy on serum immunoglobulin levels: results of a randomized controlled trial. Ann Allergy Asthma Immunol. 2006 Aug; 97(2):251-6. PMID: 16937760 [PubMed - indexed for MEDLINE]

  • van Kooij B, Rothova A, Rijkers GT, de Groot-Mijnes JD.
    Distinct cytokine and chemokine profiles in the aqueous of patients with uveitis and cystoid macular edema. Am J Ophthalmol. 2006 Jul; 142(1):192-4. PMID: 16815285 [PubMed - indexed for MEDLINE]

  • Hietbrink F, Koenderman L, Rijkers G, Leenen L.
    Trauma: the role of the innate immune system. World J Emerg Surg. 2006 May 20; 1:15. PMID: 16759367 [PubMed - in process]

  • Wiertsema SP, Herpers BL, Veenhoven RH, Salimans MM, Ruven HJ, Sanders EA, Rijkers GT.
    Functional polymorphisms in the mannan-binding lectin 2 gene: effect on MBL levels and otitis media. J Allergy Clin Immunol. 2006 Jun; 117(6):1344-50. Epub 2006 Apr 27. PMID: 16750996 [PubMed - indexed for MEDLINE]

  • van Heerbeek N, Straetemans M, Wiertsema SP, Ingels KJ, Rijkers GT, Schilder AG, Sanders EA, Zielhuis GA.
    Effect of combined pneumococcal conjugate and polysaccharide vaccination on recurrent otitis media with effusion. Pediatrics. 2006 Mar; 117(3):603-8. PMID: 16510637 [PubMed - indexed for MEDLINE]

  • Verboon-Maciolek MA, Thijsen SF, Hemels MA, Menses M, van Loon AM, Krediet TG, Gerards LJ, Fleer A, Voorbij HA, Rijkers GT
    Inflammatory mediators for the diagnosis and treatment of sepsis in early infancy. Pediatr Res. 2006 Mar; 59(3):457-61. PMID: 16492989 [PubMed - indexed for MEDLINE]

  • de Jager W, Rijkers GT
    Solid-phase and bead-based cytokine immunoassay: A comparison. Methods. 2006 Feb 13; [Epub ahead of print]

  • Brandsma D, Taphoorn MJ, de Jager W, Bonfrer H, Algra A, Reijneveld JC, Boogerd W, Korse T, Verbeek MM, Rijkers GT, Voest EE.
    Interleukin-8 CSF levels predict survival in patients with leptomeningeal metastases. Neurology. 2006 66(2):243-6.

    • 2005

  • Spanjaard L, van den Hof S, de Melker HE, Vermeer-de Bondt PE, van der Ende A, Rijkers GT.
    [Increase in the number of invasive Haemophilus influenzae type b infections] Ned Tijdschr Geneeskd. 2005 149(49):2738-42.

  • van der Velden AM, Claessen AM, van Velzen-Blad H, Biesma DH, Rijkers GT.
    Development of functional Haemophilus Influenzae type b antibodies after vaccination. Haematologica. 2005; 90:1582-4.

  • LEM. Niers, HM. Timmerman, GT. Rijkers, GM. van Bleek, NOP. van Uden, EF. Knol, ML. Kapsenberg, JLL. Kimpen, MO. Hoekstra
    Identification of strong interleukin-10 inducing lactic acid bacteria which down-regulate T helper type 2 cytokines. Clinical Experimental Allergy 35 (2005) 1481

  • Wiertsema SP, Veenhoven RH, Walraven V, Uiterwaal CS, Schilder AG, Rijkers GT, Sanders EA.
    Pneumococcal vaccine efficacy for mucosal pneumococcal infections depends on Fcgamma receptor IIa polymorphism. Vaccine. 2005 Sep 28;

  • Straetemans M, van Heerbeek N, Sanders EA, Engel JA, Schilder AG, Rijkers GT, Graamans K, Straatman H, Zielhuis GA.
    Immune status and eustachian tube function in recurrence of otitis media with effusion. Arch Otolaryngol Head Neck Surg. 2005 Sep;131(9):771-6.

  • van Kempen MJ, Vermeiren JS, Vaneechoutte M, Claeys G, Veenhoven RH, Rijkers GT, Sanders EA, Dhooge IJ.
    Pneumococcal conjugate vaccination in children with recurrent acute otitis media: A therapeutic alternative? Int J Pediatr Otorhinolaryngol. 2005 Sep 1

  • Slieker MG, Sanders EA, Rijkers GT, Ruven HJ, van der Ent CK.
    Disease modifying genes in cystic fibrosis. J Cyst Fibros. 2005 Aug;4 Suppl 2:7-13.

  • Tonnaer EL, Rijkers GT, Meis JF, Klaassen CH, Bogaert D, Hermans PW, Curfs JH.
    Genetic relatedness between pneumococcal populations originating from the nasopharynx, adenoid, and tympanic cavity of children with otitis media. J Clin Microbiol. 2005 Jul;43(7):3140-4.

  • Kamphuis S, Kuis W, de Jager W, Teklenburg G, Massa M, Gordon G, Boerhof M, Rijkers GT, Uiterwaal CS, Otten HG, Sette A, Albani S, Prakken BJ.
    Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis. Lancet. 2005 Jul 2;366(9479):50-6.

  • van Royen-Kerkhof A, Sanders EA, Walraven V, Voorhorst-Ogink M, Saeland E, Teeling JL, Gerritsen A, van Dijk MA, Kuis W, Rijkers GT, Vitale L, Keler T, McKenzie SE, Leusen JH, van de Winkel JG.
    A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice. Br J Haematol. 2005 Jul;130(1): 130-7.

  • Terheggen-Lagro SW, Rijkers GT, van der Ent CK.
    The role of airway epithelium and blood neutrophils in the inflammatory response in cystic fibrosis. J Cyst Fibros. 2005 Jun 17;

  • Wiertsema SP, Veenhoven RH, Sanders EA, Rijkers GT.
    Immunologic Screening of Children with Recurrent Otitis Media. Curr Allergy Asthma Rep. 2005 Jul;5(4):302-307.

  • de Jager W, Prakken BJ, Bijlsma JW, Kuis W, Rijkers GT.
    Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies. J Immunol Methods. 2005 May;300(1-2):124-35.

  • Breukels MA, Zandvoort A, Rijkers GT, Lodewijk ME, Klok PA, Harms G, Timens W.
    Complement dependency of splenic localization of pneumococcal polysaccharide and conjugate vaccines. Scand J Immunol. 2005 Apr;61(4):322-8.

  • Bogaert D, Veenhoven RH, Ramdin R, Luijendijk IH, Rijkers GT, Sanders EA, de Groot R, Hermans PW.
    Pneumococcal conjugate vaccination does not induce a persisting mucosal IgA response in children with recurrent acute otitis media. Vaccine. 2005 ;23: 2607-13.

  • Straetemans M, Wiertsema SP, Sanders EA, Rijkers GT, Graamans K, Van der Baan B, Zielhuis GA.
    Immunological status in the aetiology of recurrent otitis media with effusion: serum immunoglobulin levels, functional mannose-binding lectin and Fc receptor polymorphisms for IgG. J Clin Immunol. 2005;25:78-86.

  • Rijkers GT.
    Het immuunsysteem en vaccinatie.
    In: Prikken en afweer uitgediept: Praktische vaccinatievraagstukken. Visser LG, Ligthelm, Schout C en van Dissel JT (Red.) Boerhaave Commissie, Leiden 2005, pp 1-12.

  • Tonnaer ELGM, Ingels KJAO, Rijkers GT, Curfs JAHJ.
    Antigenic and nonantigenic stimuli induce similar middle ear responses in the rat.
    In: Recent Advances in Otitis Media. Lim DJ, Bluestone CD, Casselbrant M (Eds). BC Decker, Hamilton, Canada. 2005, pp 91.

  • Wiertsema SP, de Jager W, van Heerbeek N, Engel J, Straetemans M, van der Baan B, Zielhuis G, Schilder AGM, Sanders EAM, Rijkers GT.
    Luminex technology for analysis of cytokine patterns in middle ear effusions.
    In: Recent Advances in Otitis Media. Lim DJ, Bluestone CD, Casselbrant M (Eds). BC Decker, Hamilton, Canada. 2005, pp 62-63.

  • Van Kempen, M, Vaneechoutte M, Claeys G, Rijkers G, Sanders E, Dhooge I.
    Pneumococcal colonization and the outcome of vaccination in otitis-prone children.
    In: Recent Advances in Otitis Media. Lim DJ, Bluestone CD, Casselbrant M (Eds). BC Decker, Hamilton, Canada. 2005, pp 224.

  • Wiertsema SP, Straetemans M, Walraven V, van Heerbeek N, Schilder AGM, Zielhuis GA, Rijkers GT, Sanders EAM.
    Fc receptor polymorphisms in children with recurrent otitis media.
    In: Recent Advances in Otitis Media. Lim DJ, Bluestone CD, Casselbrant M (Eds). BC Decker, Hamilton, Canada. 2005, pp 268.

  • Van Heerbeek N, Ingels KJAO, Straetemans MM, Wiertsema SP, Schilder AGM, Zielhuis GA, Rijkers GT, Sanders EAM.
    Effect of combined pneumococcal conjugate and polysaccharide vaccination on recurrent otitis media with effusion: preliminary results.
    In: Recent Advances in Otitis Media. Lim DJ, Bluestone CD, Casselbrant M (Eds). BC Decker, Hamilton, Canada. 2005, pp 282.

  • Veenhoven RH, Bogaert D, Uiterwaal CSPM, Hermans PWM, de Groot R, Kuis W, Rijkers GT, Schilder AGM, Sanders EAM.
    Effect of pneumococcal vaccination on acute otitis media and nasopharyngeal carriage in children with recurrent otitis media.
    In: Recent Advances in Otitis Media. Lim DJ, Bluestone CD, Casselbrant M (Eds). BC Decker, Hamilton, Canada. 2005, pp 290-292.

  • Rijkers GT, Veenhoven RH, Uiterwaal CSPM, Kuis W, van Schaik M, Schilder AGM, Sanders EAM.
    Immunologic evaluation of children with recurrent otitis media.
    In: Recent Advances in Otitis Media. Lim DJ, Bluestone CD, Casselbrant M (Eds). BC Decker, Hamilton, Canada. 2005, pp 370.

  • Wiertsema SP, van den Hof S, Berbers GAM, Breukels MA, Schilder AGM, Sanders EAM, Rijkers GT.
    Clinical relevance of determination of antibodies after measles, diphtheria, and Haemophilus influenzae type b vaccination of children with otitis media.
    In: Recent Advances in Otitis Media. Lim DJ, Bluestone CD, Casselbrant M (Eds). BC Decker, Hamilton, Canada. 2005, pp 371-372.

  • van Kessel DA, van Velzen-Blad H, van den Bosch JM, Rijkers GT.
    Impaired pneumococcal antibody response in bronchiectasis of unknown aetiology. Eur Respir J. 2005;25:482-9.

  • Straetemans M, van Heerbeek N, Schilder AG, Feuth T, Rijkers GT, Zielhuis GA.
    Eustachian tube function before recurrence of otitis media with effusion. Arch Otolaryngol Head Neck Surg. 2005;131:118-23.

  • Niers LE, Rijkers GT, Timmerman HM, Knol EF, Hoekstra MO.
    Probiotics for cow's milk allergy: classification after intervention. J Allergy Clin Immunol. 2005 ;115:423.

  • Bogaert D, Veenhoven RH, Sluijter M, Wannet WJ, Rijkers GT, Mitchell TJ, Clarke SC, Goessens WH, Schilder AG, Sanders EA, de Groot R, Hermans PW.
    Molecular epidemiology of pneumococcal colonization in response to pneumococcal conjugate vaccination in children with recurrent acute otitis media. J Clin Microbiol. 2005;43(1):74-83.

    • 2004

  • van Royen-Kerkhof A, Sanders EA, Wijngaarden S, van Roon JA, Voorhorst-Ogink M, Walraven V, Gerritsen A, van Dijk MA, Kuis W, Rijkers GT, Keler T, Leusen JH, van de Winkel JG.
    Flow cytometric determination of FcgammaRIIa (CD32) polymorphism. J Immunol Methods. 2004;294:135-44.

  • Veenhoven RH, Bogaert D, Schilder AG, Rijkers GT, Uiterwaal CS, Kiezebrink HH, van Kempen MJ, Dhooge IJ, Bruin J, Ijzerman EP, de Groot R, Kuis W, Hermans PW, Sanders EA.
    Nasopharyngeal pneumococcal carriage after combined pneumococcal conjugate and polysaccharide vaccination in children with a history of recurrent acute otitis media. Clin Infect Dis. 2004;39:911-9.

  • G.T. Rijkers.
    Met het oog op immuniteit - Aangrijpingspunten van vaccins op het immuunapparaat. Tijdschr. Voor Geneeskunde 2004; 60: 1445-1450.

  • G.T. Rijkers, P.M.W. Janssens en P. Herbrink.
    Voorwoord: aanvallen en verdedigen, de chemie van de immunologie. Ned Tijdschr Klin Chem Labgeneesk 2004; 29: 132-133

  • G.T. Rijkers en P. Herbrink.
    Weefsels, cellen en moleculen: bouw en functie van het immuunsysteem. Ned Tijdschr Klin Chem Labgeneesk 2004; 29: 134-137

  • M.J.D. van Tol, E.A.M. Sanders en G.T. Rijkers.
    Humorale immuundeficiënties. Ned Tijdschr Klin Chem Labgeneesk 2004; 29: 138-144

  • Wiertsema SP, Sanders EA, Veenhoven RH, Heerbeek NV, Hof SV, Berbers GA, Rijkers GT.
    Antibody levels after regular childhood vaccinations in the immunological screening of children with recurrent otitis media. J Clin Immunol. 2004 Jul;24(4):354-60.

  • Vermeer H, Hendriks-Stegeman BI, van Suylekom D, Rijkers GT, van Buul-Offers SC, Jansen M.
    An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells. Mol Cell Endocrinol. 2004 Apr 15;218(1-2):49-55.

  • de Kleer IM, Wedderburn LR, Taams LS, Patel A, Varsani H, Klein M, de Jager W, Pugayung G, Giannoni F, Rijkers G, Albani S, Kuis W, Prakken B.
    CD4+CD25(bright) regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol. 2004 May 15;172(10):6435-43.

  • Veenhoven R, Rijkers G, Schilder A, Adelmeijer J, Uiterwaal C, Kuis W, Sanders E.
    Immunoglobulins in otitis-prone children. Pediatr Res. 2004 Jan;55(1):159-62.